Take the bite
out of fleas, ticks and mosquitoes®
K9
Advantix is for use on dogs and puppies 7 weeks of
age and older only. It is used for the relevant
prevention and treatment of fleas, mosquitoes and ticks
including deer ticks (the major carrier of Lyme
disease), American dog ticks, Brown dog ticks and lone
star ticks. K-9 Advantix kills and repels fleas, ticks
and mosquitoes.
The
active ingredients, imidacloprid and permethrin, work
together for a quick knockdown by affecting the flea,
mosquito or tick's nervous system. Because K9 Advantix®
provides such quick knockdown of these insects it can
helpful in limiting the spread of the West Nile Virus
and Lyme Disease. It is also ideal for dogs suffering
from Flea Allergy Dermatitis.
k9 Advantix for dogs is effective flea and tick treatment for
dogs.When a flea is exposed to imidacloprid on a treated
pet, the compound is absorbed through the insect's
intersegmental membrane. Here, the compound comes into
contact with the flea's nervous system. Imidacloprid
then acts inside the synapse of the insect to disrupt
transmission of the nervous impulse. Imidacloprid binds
to post-synaptic nicotinic receptor sites inside the
synapse, essentially "locking" the receptor in the open
position thus hyperstimulating the cell. As this occurs
throughout the nervous system, it leads to death of the
insect. Furthermore, imidacloprid is highly selective in
its activity. It only binds to insect nicotinic receptor
sites, showing virtually no affinity for mammalian
receptor sites. As an analogy, one may think of a lock
and key, where the insect nicotinic receptor site is the
lock and imidacloprid is the key. Imidacloprid only
"fits" the right "lock," and does not fit similar
receptor sites found in mammals.
The highly specific mode of action of imidacloprid
makes it an ideal compound for insect control. However,
it does limit its utility against ticks and mites
because they are arachnids (the same class as spiders)
rather than insects. Research has shown that
imidacloprid does not bind as well to arachnid receptors
as it does to insect receptors. For this reason,
imidacloprid is not utilized as a stand-alone ingredient
for canine tick control. Rather, its limited activity
against ticks is best exploited to enhance the efficacy
of other compounds, permethrin in particular.
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